Increasingly more people are turning to therapeutic peptides to shed weight. Around 12% of adults have taken a particular category of weight loss peptides called glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and combined sales of the most popular GLP-1 RAs have grown by 89% since 2022.
Because commercials can tell you only so much, you need other resources to see whether a particular treatment is the one for you. This guide to the best peptides for weight loss integrates all of the most valuable information on the topic — on GLP-1 RAs as well as non-GLP-1 alternatives — to help steer you toward the right decision for your health.
For the quickest rundown of our findings, here is a handy summary of recommendations directly below. Then you can read through the rest of the guide to understand how we made our selections.
Most scientifically supported for weight loss: Tirzepatide
Most accessible: Semaglutide
Best non-GLP-1 peptide for moderate weight loss: Tesamorelin
Our team has also built relationships with medical providers who prescribe weight loss peptides, giving us a closer view of the medicine’s effects on users than you can find from other sources.
Additionally, like all health-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for accuracy and will continue to be monitored for updates by our editorial team.
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